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Old 02-27-2008, 01:41 PM   #11
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"Capsaicin is a neurotoxin that destroys small sensory neurons with unmyelinated axons, including a subpopulation of vagal sensory neurons. Capsaicin treatment attenuates suppression of food intake induced by systemic administration of cholecystokinin (CCK) but not by gastric distension. However, both gastric distension and intravascular CCK alter the discharge of dorsal hindbrain neurons by a vagal mechanism. Therefore, it is plausible that some hindbrain neurons receive convergent input from capsaicin-sensitive vagal neurons that are responsive to CCK and also from capsaicin-insensitive neurons that are responsive to gastric distension. "

Whatever that means.


You sliver-tongued devil, you. I couldn't have said it better myself!
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Old 02-27-2008, 01:41 PM   #12
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Whoa! I knew it was a stimulant like caffiene, but not a neurotoxin! My BF is addicted to hot peppers. He can't get enough. I've never seen him break a sweat. It's not showing off, it really just doesn't bother him.
The addiction is literally true Eating hot peppers causes pain, which causes the brain to release endorphins, the pleasure hormones. The more you eat, the more you need to get the same effect. I'm on my way - I'm putting Texas Pete on my leftover spaghetti now

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Once he caught me removing the seeds and he didn't talk to me for a day.
That's kinda weird

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Is he losing brain cells?

Will he be physically (or neurologically) hurt if I find him the Jolokia peppers?
It looks like capsaicin is used as a treatment for a variety of ills: site:mayoclinic.com Capsaicin - Google Search

I doubt it's hurting him.
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Old 02-27-2008, 01:46 PM   #13
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This page says capsaicin is actually good for you: Molecular Expressions: Phytochemical Gallery - Capsaicin

Bring it on!
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Old 02-27-2008, 01:48 PM   #14
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it IS good for you, but like anything else, Too Much.....


well I`m sure you know the rest ;)
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Old 02-27-2008, 01:56 PM   #15
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it IS good for you, but like anything else, Too Much.....


well I`m sure you know the rest ;)
I hear ya, YT. It seems like the more I have, the more I want, though. The last couple of times I've been to my favorite Thai restaurant, I've asked for the special spicy sauces that are only served on request And when I made pizza last night, I doctored up the jarred sauce with garlic, basil, oregano -- and crushed red peppers
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Old 02-27-2008, 02:09 PM   #16
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I am currently addicted to red Thai peppers... holland or cayenne type.
They do short circuit my neurons.. the ones that control sweating from the
scalp, LOL!

They are just hot enough to be good without causing too much pain.
Gotta have flavor or the hot is a waste of time... and tears! ;)
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Old 02-27-2008, 02:13 PM   #17
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Gotta have flavor or the hot is a waste of time... and tears! ;)
Therein Lays the REAL Truth!

if you dont like the flave or aroma, try a different type of Chili, no matter HOW "Hot" it is, if the best bit isn`t there, it`s no good!

Any idiot can make something stupidly HOT, it takes skill to get it Just-Right though
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Old 02-27-2008, 02:15 PM   #18
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This report (pages 3-4) tells about how a large dose of Capcaisin damages certain brain cells that are sensory receptors. That's why you can become desensitized. The damage is reversible, as the cells regenerate, but they don't reinnervate (To restore nerve function after it has been lost). High doses of capsaicin cause terminal degeneration, axon degeneration (axon: the fiber of a nerve cell that sends messages to the body) , and impaired nociception (activity in the nervous system that results from stimulating pain receptors).

So, it sounds to me like the real damage is: Capcaisin kills the cells responsible for making you feel the effects of the capcaisin, which in turn increases your ability to tolerate the capcasin. So anything to which you can gain a tolerance must be a neurotoxin, because the tolerance is achieved through the destruction of sensory brain cells...
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Old 02-27-2008, 02:24 PM   #19
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Capcaisin kills the cells responsible for making you feel the effects of the capcaisin, which in turn increases your ability to tolerate the capcasin.
How very clever of it!!
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Old 02-27-2008, 02:26 PM   #20
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How very clever of it!!
I LOVE THAT!!!
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