I grow about 25-30 plants each year, depending on how carried away I get when I start my seeds.
I use cattle panels* and T-posts instead of cages. I set the panels in parallel rows, about 18 inches apart, tomato plants in the middle. I set the plants about 2 feet apart.
Once that is done, the only chore is walking the row a couple times a week, stuffing errant branches back inside the panels.
*Cattle panels are 16 feet long by 4.5 feet high, made of heavy gauge wire. They cost (last year) about $20 each at the farm store. Cattle panels are also great for grapes (see the bottom pix) or other vines--just make them into an arch. They can be cut, if you have a smaller garden.