Charlie, this makes me think of one of my very favorite "comfort" foods, which is Vegetable Soup made from homemade beef stock -- nothing else like it in the world, IMO.
Roast the bones, as mudbug suggested, with or without vegetables (I omit). Then dump the bones into a large stockpot, add enough water to cover, then add that same amount again. Then slowly simmer all day long, even overnight if you wish. Voila! Beef stock! And with a flavor that cannot be compared.
The stock can be used in almost limitless fashion...in anything that calls for beef bullion or stock. As I said, my favorite soup utilizes beef stock, plus any vegetable I have on hand: beans, corn, peas, broccoli, asparagus, onions -- nothing is sacrosanct! Season with salt and pepper to taste, make a big pan of corn bread....and stand aside so that I don't knock you over getting to the stuff!
Pain is inevitable. Suffering is Optional.