I like to sear the roast, brown some onions and garlic, put it all in a dutch oven or lidded skillet, pour a bottle of beer over the roast, and cook slowly for a couple of hours. Add some thyme and rosemary, if you like, and salt and pepper.
My sister puts in a packet of Italian dressing mix---that is good, too.
Even if you don't like the taste of beer, you will like this pot roast.
I just haven't been the same
since that house fell on my sister.