I don't shop thrift stores often because, quite simply, my home IS a thrift shop! Close to half my non-clothing possessions are hand-me-downs. However, when visiting family or friend away, occasionally they will suggest a stop at a hospital's or ladies guild-type of thrift shop. Those keep their funds in-house to help their neighborhoods. They also seem to have the best deals. We have a couple of these stand-alone shops in towns near us. They might end up with my leftovers. But this thread has given me more to think about.
Tinlizzie, if you don't use an object but you don't want to let go because you think you might lose the memories, take a photo and use it for a little album. Picture on one side, small story about the item and the memories it brings on the other. That way you never really get rid of the thing or memories.